Intrauterine Insemination (IUI)

Intrauterine insemination is a popular fertility treatment wherein the sperm is injected inside the female uterus for successful fertilization. The procedure aims to facilitate fertilization by maximizing the number of sperms reaching the fallopian tubes. IUI gives the sperm the desired push but still requires it to reach and fertilize the egg on its own. It is a less invasive and expensive option compared to in vitro fertilization (IVF).

When is IUI used?

Decreased sperm mobility or low sperm count is the most common reason for using IUI.

However, IUI may be a chosen fertility treatment for any of the following conditions as well:

  • Unexplained infertility
  • A hostile cervical condition like unusual cervical mucus discharge
  • Cervical scar tissues from a past procedure that prevents the sperm from entering the uterus
  • Ejaculation dysfunction

IUI is usually not recommended for the following patients:

  • Women who have fallopian tube disorders
  • Women who suffer from pelvic infections
  • Women with endometriosis (moderate to severe)

How does IUI work?

Medications will likely be prescribed to stimulate ovulation before IUI procedure. In such a case, the eggs need to be monitored carefully until they mature. IUI will be performed around the time of ovulation, usually 24-36 hours after there is a surge in LH hormone. This suggests that ovulation will occur shortly.

A semen sample is washed in the lab to separate the semen from the seminal fluid. Then, the sperm will be inserted directly into the uterus using a catheter. This process helps maximize the number of sperm cells that are placed in the uterus, boosting the possibility of conceiving. IUI takes only up to a few minutes and involves minimal discomfort.

How successful is IUI?

The success of IUI depends on several factors. If a couple gets the IUI procedure done every month, the rate of success per cycle may be as high as 20%. However, this depends on several variables, like age of the female, use of drugs, reasons for infertility, and others. IUI is a minimally invasive and relatively cheap alternative to the conventional IVF procedure. However, the rate of pregnancy from IVF is higher than IUI. If you think you may be interested in IUI, talk with your doctor to discuss your options.

The procedure

For Women

If you are not taking fertility drugs, IUI will be performed between day 12 and 16 of your menstrual cycle with day one being the first day of your period. You will be given blood or urine tests to identify when you are about to ovulate.

Or

If you are taking fertility drugs that stimulate ovulation, you will have to undergo vaginal ultrasound scans to track egg development. Then, once an egg matures, you are given a hormonal injection to stimulate its release.

The sperm is inserted after about 36-40 hours. Then, just as done in a smear test, a speculum will be pushed into the vagina to keep its walls apart. Next, a catheter will be inserted through your cervix into the womb. The best quality sperm will then be selected and inserted via the catheter into your uterus.

The whole process only takes only about a few minutes and is usually painless. Some women may experience temporary, menstrual cramping. You may want to rest for a short time before going home.

For Men:

You will be asked to produce a sperm sample on the day the treatment takes place.

Your partner’s sperm will be washed to remove the fluid surrounding them and then the rapidly moving ones will be separated from the slower ones.

The latter will be placed in a small catheter to be inserted into the womb.

If you are using frozen or donated sperm, it will first be removed from the storage, thawed, and then, prepared.

Risks

IUI is a relatively simple and safe procedure and the risk of serious complications is low. The process itself isn’t associated with an increased risk of multiple pregnancies – twins, triplets, or more. But, when ovulation-inducing medications are used, the chance of multiple pregnancies increases. Quite naturally, multiple pregnancies have a higher risk than a single pregnancy.

To know more about the side effects caused by fertility drugs, contact your doctor.

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