Tag Archives: Pregnancy Loss

Miscarriage: Cause & Impact

miscarriage

A “spontaneous miscarriage” is the loss of a pregnancy before gestation of 20 weeks. Nearly 80% of spontaneous miscarriages occur within the first 12 weeks of pregnancy. While approximately one in four pregnancies end in miscarriage, many of these unfortunate events aren’t detected since these occur very early during pregnancy.

What causes a miscarriage?

A miscarriage usually occurs because the pregnancy is not developing properly. While a large number of miscarriages occur as a result of genetically abnormal embryos, there could be a plethora of factors responsible. These include:

# Random chromosome disorders

# Blood clotting disorders

# Hormonal disorders

# Submucosal fibroids

# Structural abnormalities in the womb

# Hormonal issues linked to polycystic ovaries

# An inherited genetic abnormality

# Being over 35 years of age, with a decline in quality of eggs

# For men over 40, the quality of sperm decreases, raising the risk of miscarriage

How does a woman understand that she’s having a miscarriage?    

Look out for the following signs:

# Heavy bleeding

# Severe abdominal or shoulder pain

# Fever or chills

# Dizziness or fainting

# Vaginal discharge with an unpleasant odor

# Diarrhoea or cramps

A miscarriage can trigger a whole gamut of emotional upheaval, particularly in the woman. Regardless of whether the pregnancy is planned or unplanned, the emotional impact of miscarriage can be great, and that’s perfectly normal. A sense of profound loss is very common and expected, and though people may react differently to this tragic event, the loss can bring on:

# A sense of total emptiness

# Anger and utter disbelief

# A crestfallen feeling

# Acute melancholy and a sense of isolation

But remember that it’s important to stay positive while riding out the emotional rollercoaster, and summon up enough courage and willpower to try again. This is when one needs the love and support of family and friends. Do not shut out the people who care for you and do not hesitate to turn to them for encouragement and support.

Do not give up hope, you have to try again!

However, while trying for another pregnancy after a miscarriage, remember to:

# Quit smoking

# Exercise regularly and follow a balanced diet

# Reduce stress

# Watch your weight

# Take folic acid tablets

Is any treatment required for a miscarriage?

Once a miscarriage has begun, it can’t be reversed. So the doctor would typically try to prevent heavy bleeding and infection as the main treatment protocols, besides providing emotional support. Heavy bleeding with clots and cramps would indicate that the patient is still passing the pregnancy tissue. These symptoms should settle once most of the pregnancy tissue has been passed.

Sometimes, following a miscarriage, some residual pregnancy tissue remains in the uterus. Doctors then use a spoon-shaped instrument called a curette to scrape the uterus, a procedure called ‘dilation and curettage’, usually performed under a light general anaesthetic and the patient can go home the same day.

The role of IVF in miscarriage

In recurrent miscarriages, IVF or In Vitro Fertilization with genetic testing “can significantly minimize the risk of miscarriage and improve chances for a safe and successful pregnancy”.

# Genetic screening: Since genetic abnormalities in the embryo are the most prevalent cause of miscarriage, genetic screening is a very useful tool.

# Embryo screening: Doctors can now screen for chromosomal abnormalities and identify the healthiest embryo for implantation with a very high degree of accuracy.

# Frozen embryo transfer: In thisform of IVF treatment, a cryopreserved embryo created in a full IVF cycle is thawed and transferred to a uterus.

# Single embryo transfer: In thisprocedure, a single embryo, selected from a larger pool of available embryos, is placed in the uterus. 

# Fertility care: This is extremely beneficial since tests prior to treatment can determine the risk for miscarriage and, possible contributing factors.

# Supervision & monitoring: Close supervision and monitoring is part of fertility care and helps mitigate risk and optimize chances for an ongoing pregnancy and live birth.

A miscarriage is more often than not precipitated by a combination of factors over which one had little control and it’s a wrong notion that the event has a propensity to recur. Women who have miscarried once or twice, are usually not sent for tests since it’s highly unlikely that anything would be found amiss. However, those who have had three back-to-back miscarriages, are at risk of miscarrying again, and must seek medical advice.

5 Things You Should Know About Recurrent Pregnancy Loss (RPL)

Recurrent Pregnancy Loss

Pregnancy loss is usually hard to deal with and difficult to discuss. It is sad and personal, but not uncommon or unnatural. Certain myths surrounding pregnancy losses  often make it harder for the person going through it. This blog tries to unravel long-standing misconceptions about pregnancy, miscarriage, and recurrent pregnancy loss and start an open conversation that may lift the burden of secrecy and stigma, and help couples cope with recurrent pregnancy loss, understand the furture implications. 

What is Recurrent pregnancy loss?

Recurrent pregnancy loss or RPL is defined as having two or more miscarriages. After two miscarriages, an examination and testing are recommended.

What tests are available to find the causes of repeated miscarriages?

To help find the cause of repeated miscarriages, your healthcare professional will ask about your medical history and past pregnancies. A complete physical exam, including a pelvic exam, might be conducted. You may have to undergo blood tests to detect underlying issues with the immune system. Testing can be done to detect genetic causes of repeated pregnancy losses. Imaging tests may be considered to find if a uterine problem is causing recurrent pregnancy loss.

Can recurrent pregnancy loss cause infertility?

There is no evidence to suggest that RPL causes infertility. However, there is a possibility that a woman who has experienced pregnancy loss might experience another. This is most commonly due to underlying health conditions.

What causes recurrent pregnancy loss?

According to ACOG, approximately 60% of all recurrent miscarriages are a result of a genetic abnormality. As a woman ages, the risk of miscarriage resulting from genetic abnormalities increases – from 15 to 20% if she is under 35, to more than 50% if her age is over 40. The common causes of pregnancy loss include the following:

Genetic abnormalities

Genetic abnormalities can occur when an embryo is the recipient of an abnormal number of chromosomes during fertilization. In approximately 2–5% of couples with recurrent miscarriage, one of the partners carries a balanced structural chromosomal anomaly (Reciprocal or Robertsonian translocation). Their pregnancies are at ncreased risk of miscarriage and may result in a live birth with unbalanced chromosomal arrangement. The risk of miscarriage is influenced by the size and genetic content of the rearranged chromosomal segments.

Anatomic abnormalities

A septet uterus, in which a wall of tissue divides the uterus into two sections, occurs commonly and may result in recurrent pregnancy losses. While it is not clear why this leads to recurrent pregnancy losses, some believe that poor vascularity in the septum prevents the embryo from growing if it implants there. If the pregnancy makes it to term, the fetus may be breech. However, removing a uterine septum is easy surgically. An incompetent cervix cannot remain closed due to weakened muscles. As the developing fetus reaches a certain weight, the weakened cervix cannot support the fetus and often results in miscarriage.

Medical conditions

Certain medical conditions tend to increase the risk of recurrent pregnancy losses, including:

  • Antiphospholipid syndrome (APS) – An autoimmune disorder that occurs when a person’s immune system makes antibodies necessary for blood clotting
  • Thyroid/hormonal issues – An overactive or underactive thyroid can result in hormonal imbalances, which can cause a miscarriage if the uterine lining does not develop normally for implantation and nourishment of a fertilized egg. Elevated prolactin (reproductive hormone produced in the pituitary gland) levels can alter the development of the uterine lining
  • Fibroids and polyps – Non-cancerous growths that can invade the uterus
  • Asherman’s syndrome – A condition where scar tissue forms inside the uterus, causing miscarriage

How is Recurrent Pregnancy Loss treated?

The treatment of RPL must be based on imaging, clinical, and laboratory findings. Couples in which one of the partners carries a chromosomal rearrangement or abnormality should be referred for genetic counseling to discuss the probability of viable pregnancy based on the chromosomes involved. Women with intrauterine adhesions, a uterine septum, or uterine fibroids (especially submucosal fibroids) can choose surgical corrections, which per research is associated with reduced risk of pregnancy losses.

Next Steps Following Pregnancy Loss

It is essential to know that pregnancy loss does not mean that you will not be able to have children. Most people suffering a miscarriage will go on to give birth to a healthy baby. Even if pregnancy loss is recurrent, there are still treatment options. Besides a fertility specialist, a reproductive endocrinologist is often the go-to-specialist (or is part of the team) that offers treatment for recurrent pregnancy loss.

What to Expect from a Fertility Specialist in Kolkata Following an RPL?

Your experience with a recurrent miscarriage specialist will start with a consultation visit where you can expect to discuss the medical history and plan further evaluation. For a thorough diagnosis, your partner also needs to attend the initial appointment. Depending on your needs, you may be referred to a fertility specialist in Kolkata, who may ask you to take a range of tests, including some anatomical, hormonal, and autoimmune ones. Those undergoing the procedures can get home the same day. Once a fertility specialist is aware of the problem, they can even recommend a fertility treatment plan tailored for your needs.